Bim Rabbit pAb (APR19184N)
产品名称: Bim Rabbit pAb (APR19184N)
英文名称: Bim Rabbit pAb (APR19184N)
产品编号: APR19184N
产品价格: null
产品产地: 美国
品牌商标: Leading Biology
更新时间: null
使用范围: WB (Mus musculus)
安诺伦(北京)生物科技有限公司
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分子量:Calculated MW: 4-22kDa 细胞定位:Endomembrane system, Mitochondrion, Peripheral membrane protein 稀释方法:IHC 1:50 - 1:100 IF 1:50 - 1:100 总结:The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.