分子量：Calculated MW: 89kDa
Observed MW: 80kDa

细胞定位：Cytoplasm, Lysosome, Nucleus

稀释方法：WB 1:500 - 1:2000

总结：This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.