Leptin Receptor Rabbit pAb (APR25064N)
产品名称: Leptin Receptor Rabbit pAb (APR25064N)
英文名称: Leptin Receptor Rabbit pAb (APR25064N)
产品编号: APR25064N
产品价格: null
产品产地: 美国
品牌商标: Leading Biology
更新时间: null
使用范围:
安诺伦(北京)生物科技有限公司
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分子量:Calculated MW: 96kDa/102kDa/103kDa/109kDa/132kDa Observed MW: 140KDa 细胞定位:Cell membrane, Secreted, Single-pass type I membrane protein 稀释方法:WB 1:500 - 1:1000 IF 1:50 - 1:200 总结:The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).