MDM2 Mouse Monoclonal Antibody [Clone ID: LBI1B4]-抗体-抗体-生物在线
安诺伦(北京)生物科技有限公司
MDM2 Mouse Monoclonal Antibody [Clone ID: LBI1B4]

MDM2 Mouse Monoclonal Antibody [Clone ID: LBI1B4]

商家询价

产品名称: MDM2 Mouse Monoclonal Antibody [Clone ID: LBI1B4]

英文名称: MDM2 Mouse Monoclonal Antibody [Clone ID: LBI1B4]

产品编号: AMM15220V

产品价格: null

产品产地: 美国

品牌商标: Leading Biology

更新时间: null

使用范围: WB 1:2000

安诺伦(北京)生物科技有限公司
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别名:ACTFS; hdm2; HDMX

产品概述:MDM2 mouse monoclonal antibody, clone LBI1B4

总结:This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq, Jul 2008]