TLR4 Rabbit pAb (APR18382N)
产品名称: TLR4 Rabbit pAb (APR18382N)
英文名称: TLR4 Rabbit pAb (APR18382N)
产品编号: APR18382N
产品价格: null
产品产地: 美国
品牌商标: Leading Biology
更新时间: null
使用范围: WB (Mus musculus, Rattus norvegicus, Homo sapiens)
安诺伦(北京)生物科技有限公司
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分子量:Calculated MW: 73kDa/91kDa/95kDa Observed MW: 96KDa 细胞定位:Cell membrane, Single-pass type I membrane protein 稀释方法:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 总结:The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.