LCP2 polyclonal antibody
产品名称： LCP2 polyclonal antibody
英文名称： LCP2 polyclonal antibody
产品编号： PAB6649
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Goat polyclonal antibody raised against synthetic peptide of LCP2.
- Immunogen:
- A synthetic peptide corresponding to human LCP2.
- Sequence:
- ALRNVPFRSEV-C
- Host:
- Goat
- Theoretical MW (kDa):
- 60.2
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Antigen affinity purification
- Concentration:
- 0.5 mg/mL
- Storage Buffer:
- In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:32000)
Western Blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells.
Jackman JK, Motto DG, Sun Q, Tanemoto M, Turck CW, Peltz GA, Koretzky GA, Findell PR.J Biol Chem. 1995 Mar 31;270(13):7029-32.
- Entrez GeneID:
- 3937
- Protein Accession#:
- NP_005556
- Gene Name:
- LCP2
- Gene Alias:
- SLP-76,SLP76
- Gene Description:
- lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
- Omim ID:
- 601603
- Gene Ontology:
- Hyperlink
- Gene Summary:
- SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq
- Other Designations:
- 76 kDa tyrosine phosphoprotein,SH2 domain-containing leukocyte protein of 76kD,lymphocyte cytosolic protein 2,lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)
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